This paper briefly expounds the basic principle of structure isolation, reviews the development process of isolated technology. Adopting the common and base isolation system and inputting El-Centro as the earthquake wave, in this paper, comparative analysis of structure’s earthquake-resistant performance was conducted on a 6-layer custom steel structure residence in Changzhou area. The result shows that the gradually matured seismic isolated technology can be applied to steel structure as well, which means the seismic isolation steel structures possess the same characteristics as other seismic isolation structures. With the satisfaction of required bearing capacity, the structural reaction to earthquake has been effectively reduced and its safety has been guaranteed after considering the seismic isolation of steel structure residence; moreover, the storey accelerations reaction has also been greatly declined, meeting higher requirements towards comfortableness of residence structure. Meanwhile, by nonlinear dynamic analysis of simple Bouc-Wen hysteretic model, the requirement towards the biggest ductility was discussed and a brief analysis of the life cycle cost of this residence was worked out. The analysis result demonstrates that the seismic isolation layer has effectively controlled the vibration of superstructure, which would contribute to the reduction of seismic hazard.