Considering the interaction of building-soil-tunnel, the grillage beams foundation frame building vertical crossed by Double-Line (DL) parallel shield tunnel was simulated by 3D MIDAS/GTS software. The results show that: after left-shield tunnel construction had done, during the passage of the right shield tunnelling, the differential settlement decreased gradually, settlement is slightly larger than the left when the right tunnel had ready crossed the building. Uneven settlement first increases, and then decreases gradually tends to zero. Lateral horizontal displacement changes little, and longitudinal horizontal displacement first increased and then decreases. The building’s maximum first principal stress exceeds the standard value, which may cause cracking. With the increase of L the distance from frame axis to the axis of the two tunnels, the first principal stress P1 and maximum shear strain MSmax tended to reduce in general. The maximum differential settlement between columns first increased and then decreased.