The purpose of this paper is to solve issues in current hospital such as complex process, large time-consumption and monotony of space design. The research in the paper introduced the principle of matrix with sections and departments as elements, streamline traffic as transmission path of signals, people seeing doctor as method of signals. Therefore, a fresh model of hospital design was made. The result of the research showed its guiding line for hospital design under the new condition. The unique feature of the research is that design innovation was made in hospital design by integrating of knowledge of different disciplines.