The purpose of this study was to investigate the effect of pigmentation on the flexural strength of dental Y-TZP/porcelain layered structure. KaVo™ Everest zirconia substructures was pigmented by dipping presintered blocks in coloring solution, and colored TZ-3YS zirconia substructures were fabricated by adding pigments before isostatically pressing. Specimens were made in monolithic or bilayered forms. The bending strength was tested. XRD and SEM with EDX were used to analyze the characteristics of the surface structure. Experimental results showed that there were significant differences of bending strength in both zirconia systems between white and colored monoclinic materials, which also in bilayered structures. Pigmentation has no apparent effects on the bonding strength between veneering porcelain and zirconia. Both coloring methods are appropriate when the concentration of pigments is under deliberate controlled.