Superfine nanometer SrTiO3 with size of near 50-60nm was prepared by citrate process and sol-gel method. XRD and TEM characterizations indicate that sol-gel method is appropriate to prepare high-purity powders at far lower temperature than other methods. The Ni-based catalysts were prepared by using SrTiO3 powder as support through impregnation and sol-gel method. These catalysts were applied to the reaction of CO2 reforming CH4 to synas and showed high activity. The catalytic activity of Ni-based catalyst is investigated by reaction temperature, the method of support preparation, and the method of catalyst preparation; It shows that the catalyst possesses higher catalytic activity with the increasing of temperature; and the catalytic rate is near 90% at 973 K; and the catalyst show higher catalytic activity when support is prepared by sol-gel method than by citrate process; and the catalyst shows better catalytic activity when catalyst is prepared by sol-gel method than by impregnation method.