As certain refractory molybdenum with degree high oxidation and high argillization, on the premise of molybdenum concntrate recovery rate, in order to increase tenor of molybdenum concntrate, we use cyclonic static micro-bubble flotation column as concentration equipment. We used two concentrate courses to replace flotation machine eight concentrate courses. It showed that, in the condition of same recovery rate, tenor of molybdenum concntrate was 26.16%, rising by 8%. Using processes of flotation machine eight concentrate courses - concentrate regrinding - flotation column two concentrate courses, tenor of molybdenum concntrate was 39.33% and the recovery rate was of 8%. The results showed that, by increasing the degree of monomer dissociation of molybdenum ores, cyclonic static micro-bubble flotation column has higher capability in recovering and selecting ores of -400 mm size fraction. The high argillization resulting from the regrinding and unsuppressed gangue minerals are the main factors affecting the tenor of ore concentrate.