This study was aimed at the development of a green and reusable catalyst for Friedel-Crafts acylation. Firstly, Hydroxyapatite (HAP) and Hydroxyapatite-zinc bromide (HAP-ZnBr2) have been prepared by the co-precipatation method and hydrothermal method respectively. Their structures were characterized by X-ray Diffraction (XRD), Brunauer-Emmett-Teller (BET) and Infrared Spectroscopy (IR). The catalytic efficiency of HAP-ZnBr2 was examined for Friedel-Crafts acylation of anisole. The results showed that the catalyst was green, high activity, high selectivity and it could be reused at least 5 times without obvious activity loss.