Paper Title:
The Development of Gelatin/Chitosan Hybrid Scaffold for Mouse Embryonic Stem Cell Line ATDC5
  Abstract

Functional scaffolds fabricated from biopolymers are of great importance for tissue engineering. In this paper, by mimicking the combination of two major components in Extracellular Matrix – collagen and polysaccharide respectively, we fabricated gelatin and chitosan hybrid sponge for cartilage tissue engineering. Extending previous results of gelatin/chitosan film showed that all the hybrid coating film (chitosan: gelatin= 4:1; 1:1; 1:4) can support the adhesion of ATDC5 that comparable to Tissue Culture Dish (TCD). More importantly, stem cell line ATDC5 on coating dish of chitosan: gelatin=1:4 showed enhanced differentiation rate than that on other films and TCD. For three dimensional scaffolds, we fabricated hybrid sponge scaffold of chitosan: gelatin=4:1, 2:1, 1:1, 1:2, 1:4 respectively. Morphological characterizations of the sponges showed that this kind of gelatin/chitosan hybrid scaffold is promising for application in cartilage tissue engineering.

  Info
Periodical
Advanced Materials Research (Volumes 123-125)
Edited by
Joong Hee Lee
Pages
395-398
DOI
10.4028/www.scientific.net/AMR.123-125.395
Citation
Y. Li, N. Matsuda, X. X. Bao, A. Teramoto, K. Abe, "The Development of Gelatin/Chitosan Hybrid Scaffold for Mouse Embryonic Stem Cell Line ATDC5", Advanced Materials Research, Vols. 123-125, pp. 395-398, 2010
Online since
August 2010
Export
Price
$32.00
Share

In order to see related information, you need to Login.

In order to see related information, you need to Login.

Authors: Andrada Serafim, Daniela G. Petre, Adriana Lungu, Horia Emil Cioflan, Izabela Cristina Stancu
Chapter 1: Biomaterials
Abstract:This work describes the investigation of the properties of hydrogels based on methacrylamide-modified gelatin (GelMA) and...
54
Authors: Jia Horng Lin, Chih Kuang Chen, Chien Lin Huang, Ssu Chieh Huang, Ching Wen Lou
Chapter 2: Nanomaterials and Nanotechnologies
Abstract:This study combines polyvinyl alcohol (PVA) and gelatin with various ratios and administers different voltages to make PVA/gelatin...
178
Authors: Jakub Mielczarek, Grzegorz Gazdowicz, Jakub Kramarz, Piotr Łątka, Marcin Krzykawski, Artur Miroszewski, Paweł Pieczarko, Renata Szczelina, Piotr Warchoł, Sonia Wróbel
Chapter 4: Researching and Designing of Technologies, Machines and Apparatus for Technological Systems in Mechanical Engineering
Abstract:3D bioprinting is an innovative method of manufacturing three-dimensional tissue-like structures. The method is based on a layer-by-layer...
221