Sodium alginate and Chitosan are common bio-medical dressing material, and drug delivery due to their excellent biocompatibility, biodegradability and non-toxicant. The purpose of dressing aimed at accelerating wound healing. In this study, sodium alginate/Chitosan composite solution composed of Chitosan particles and well-stirred sodium alginate solution. The PLA/cotton nonwoven was the base fabric. The sodium alginate/Chitosan composite solution was later sprayed upon the fabric, so a sodium alginate/Chitosan/PLA/absorbent cotton composite dressing was prepared. Calcium chloride was applied to strengthen the bonding between the sodium alginate/Chitosan solution and the fabric. Mechanical property and SEM of the sodium alginate/Chitosan/PLA/ absorbent cotton composite dressing’ were evaluated.