A grain-arranged diamond wheel was developed and grinding performance of the wheel against aluminum alloys and titanium alloy, Ti6Al4V, has been investigated using various kinds of grinding fluid. Mirror finishing of aluminum alloys was successfully performed without grinding burn when emulsion-type grinding fluid with an extreme-pressure additive was used. When oil base lubricants or a fatty acid was supplied using a MQL supply unit, fine finishing could not be done. Mesh size of the grinding wheel had only a minor effect on surface roughness. When Ti6Al4V was ground by the developed wheel, an adhesion of work material on diamond grains occurred causing the finished surface to deteriorate.