With the main objective of providing basic information for calibration of analytical models and procedures for determining seismic response of historic stone masonry buildings, a shaking table testing program was undertaken at the Institute of Engineering of UNAM. A typical colonial temple was chosen as a prototype. The model was built at a 1:8 geometric scale. Increasing levels of seismic intensities were applied to the table. Main features of the measured response are compared in this paper to those computed though a nonlinear, finite element model; for the latter, a constitutive law corresponding to plain concrete was adopted for reproducing cracking and crushing of the irregular stone masonry, which could be considered as a conglomerate with low anisotropy. From the results of the analytical models, it was found that response is strongly governed by damping coefficient and tensile strength of masonry. Measured damping coefficients were found to significantly exceed those commonly used for modern structures. Observed damage patterns as well as measured response could be reproduced with a reasonable accuracy by the analytical simulation, except for some local vibrations, as those at the top of the bell towers.