A methodology for optimization of the development of the spiral baffle based on the scientific molding approach is presented. The function of the spiral baffle, a mold cooling system components is used to convey the coolant to the tip and back in the form of a helix. It makes a very homogeneous temperature distribution of the mold. Some design parameters of the spiral baffle, such as spiral angle, pitch …etc. are important for it to achieve a good performance. In this work, we propose a methodology to optimize the design parameters based on computer aided engineering analysis and the scientific molding approach. The scientific molding is a scientific way to detect in which area a defect lies and determine the optimal molding parameters with experimental data. It provides an alternative besides the traditional optimization methods to determine the injection molding parameters, such as injection velocity, holding pressure, …, etc. In order to illustrates how to implement this methodology to determine the design parameters of the spiral baffle. The experiment is proceeded and to validate the results of the proposed method.