Because of the continuity and discreteness during production, Irradiation industry becomes one of an especial industry. Various product type, uncertain lots and complex processes cycle increase the difficulty of production planning and scheduling. The implementation of CIMS/ERP systems during product processes in the enterprise can not fulfill the special requirements especially in product automation monitoring and quality information monitoring. Research and application of scheduling method and optimization technology effect crucially for enterprise to improve its production efficiency and reduce its production cost. So, more and more scholars pay their attention to this research field. For this reason, the paper presents a mathematical production scheduling model in irradiation workshop based on the research of irradiation industry development and shop scheduling in China and abroad. The author also design an application of the irradiation shop scheduling Optimization with this model in detailed, based on described the concept, principle of genetic algorithm and its method.