Paper Title:
Organically Modified MCM-Type Material Preparation and Its Usage in Controlled Ibuprofen Delivery
  Abstract

MCM-41 functionalized by 3-aminopropyltriethoxysilane (APTMS) and 3-chloropropyltriethoxysilane (CPTMS) was synthesized, which had been used to improve the physicochemical properties of mesoporous silica to controlled ibuprofen delivery. Samples were characterized by X-ray diffraction (XRD), N2 adsorption-desorption isotherms and Fourier transform infrared (FT-IR) spectroscopy. Characterized results demonstrated that organic groups were successfully grafted onto the samples, and the mesoporous structure of the synthesized material was maintained. The results of ibuprofen release exhibited that the introduction of CPTMS greatly retarded the ibuprofen release rate, and an accumulative release achieved approximately 13.2 wt% over PClMCM-41 after 32 h. However, the introduction of APTMS greatly promoted the ibuprofen release rate, and the release of ibuprofen could increase to 26.6 wt% over PNH2MCM-41 at 32 h. Those results suggested that ibuprofen release rate could be well modulated by changing the grafted organic group.

  Info
Periodical
Advanced Materials Research (Volumes 139-141)
Edited by
Liangchi Zhang, Chunliang Zhang and Tielin Shi
Pages
222-226
DOI
10.4028/www.scientific.net/AMR.139-141.222
Citation
H. X. Yang, B. W. Cheng, Z. H. Li, K. M. Su, Q. Guo, P. Han, "Organically Modified MCM-Type Material Preparation and Its Usage in Controlled Ibuprofen Delivery", Advanced Materials Research, Vols. 139-141, pp. 222-226, 2010
Online since
October 2010
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Price
$32.00
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