In this paper, the main problem is how to eliminate vibration came from the compressor base in petrochemical industry. The absolute transmissibility was calculated by building the compressor isolation system model. The spectrum information of compressor vibration was got through the vibration test, and the results can be acted as the condition for the isolator’s design. Isolators were designed with damping part connecting metal rubber with helical spring. Nonlinear simulation calculation was completed by finite element software. The results show that the maximum stress of isolator is about 494MPa and its maximum distortion is approximately 6mm. It verifies that the new-style isolator can satisfy vibration elimination of compressor. It is with wide-range rigidity and better capability of energy dissipation than that of general rubber isolator. It has a useful application and perspective on vibration elimination for the mechanical equipment in petrochemical industry.