In order to provide theory basis for optimizing high-speed milling parameters, the high-speed milling process of titanium alloy Ti-6Al-4V was modeled using the commercial general purpose machining software package ADVANTEDGE. Effects of milling parameters like milling speed, feed per tooth, milling depth and milling width on cutting force and temperature were analyzed. The results show that cutting forces decrease with milling speed increasing, and increase with feed per tooth, milling depth and milling width, and the influences of feed per tooth, milling depth and milling width on cutting forces are significant. The maximum temperature in the cutting zone located on the rake face at a distance of about 0.02~0.03 mm from the tool tip. As milling speed and feed per tooth increase, the maximum temperature in the cutting area increases. The milling speed has significant impact on cutting temperature, but the milling depth has little impact.