In this paper, we propose a fast approach to simulate the dynamic behavior of skeletal muscles based on bio-mechanical and anatomical properties. In contrast to physically accurate deformation, this simulation achieves faster and better simulation of skeletal muscles, with the cost of unnoticeable visual accuracy. Internal constrains are generated to conserve linear and angular momentum which is essential for cloth self-collision. Deformation constraints are defined by using the muscle force-length relationship serve as Control Axial Curve, which constrainedly generates the active and passive force of the muscles to drive skeletal motion during the deformation process. This approach generates realistic visual effect, and manages the deformation of muscles on the basis of the bio-mechanical properties with fast speed. We have demonstrated the simulation by creating a musculoskeletal model of the upper limb.