According to the characteristic of high-strength strip, the roll profile configuration and change of CVC tandem cold mill are analyzed. Through the establishment of FEM model, the influences of three representative forms of roll profile configuration on high-strength strip flatness control in CVC cold rolling mill are compared, which are conventional back-up roll / CVC intermediate roll, back-up roll with CVC compensation / CVC intermediate roll, VCL+ back-up roll / HVC intermediate roll. Compared with the other two roll profile configuration, the configuration of VCL+ back-up roll / HVC intermediate roll increases 26.74% in crown adjustment domain of roll gap and 22.09% in lateral stiffness of roll gap, decreases 27.43% in contact pressure peak values between rolls. The new roll profile configuration has obtained industrial applications. Production data indicate that the control accuracy of high-strength strip is improved, also the wear of back-up roll. Significant application results have been achieved.