Ti-6Al-Mo-Fe alloys were prepared by blended elemental powder metallurgy process. In this paper, the mechanical properties and microstructure of Ti-6Al-Mo-Fe alloys sintered from the powders ball-milled for various periods of time were investigated by means of contrition behavior testing, X-ray diffraction, scanning electron microscopy. With an increase in ball milling time form 1h to 10h, the microstructure evolved into a fine β phase within the α matrix. For the Ti-6Al-Mo-Fe alloy, the yield strength and elongation increase as the milling time is prolonged. It was found that the bulk alloys made from the powders ball milled for 6 h exhibited relatively high elongation of 17.8% and high yield strength of 914 MPa.