Paper Title:
A pH/Temperature-Sensitive Semi-IPN Bead for Drug Release Carrier
  Abstract

A series of pH/temperature sensitive hydrogel beads with semi-interpenetrating polymer network (semi-IPN), composed of sodium alginate and poly(N-acryloylglycinate) were prepared as drug delivery carrier. In pH=2.3 phosphate buffer solution (PBS), the release amount of indomethacin incorporated into the beads was about 9% within 610 min, while this value approached to 68% in pH=7.4 PBS. The release rate of indomethacin was higher at 37 than that at 20 . In addition, the release amount of indomethacin was increased with increasing poly(N-acryloylglycinate) content. These results suggest that the stimuli-sensitive beads have the potential to be used as an effective pH/temperature delivery system in bio-medical fields.

  Info
Periodical
Advanced Materials Research (Volumes 148-149)
Edited by
Xianghua Liu, Zhengyi Jiang and Jingtao Han
Pages
1449-1452
DOI
10.4028/www.scientific.net/AMR.148-149.1449
Citation
K. L. Deng, Y. B. Gou, J. Zuo, L. R. Dong, Q. Li, T. Gao, "A pH/Temperature-Sensitive Semi-IPN Bead for Drug Release Carrier", Advanced Materials Research, Vols. 148-149, pp. 1449-1452, 2011
Online since
October 2010
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Price
$32.00
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