In this study, an integrated methodology combining computational modal analysis, experimental modal analysis, and computational dynamic analysis was developed to investigate unbalancing dynamic responses of high speed machining tool systems. A linear-elasticity formulation based on the finite element method (FEM) was employed to compute the natural frequencies and obtain the corresponding modal shapes. Experimental modal analysis was then performed to verify the natural frequencies. After the validation, the FEM model was further modified to predict the dynamic responses, with an HSK (a Germany abbreviation of Hohl Schaft Kegel) tool system as a model system. The results indicated that, by validating the computed natural frequencies with experimental ones, an effective simulation model can be established for predicting complex dynamic response of high speed machining tool systems.