Bone Tissue Engineering: Natural Origination or Synthetic Polymeric Scaffolds? |
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| Journal | Advanced Materials Research (Volumes 15 - 17) |
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| Volume | THERMEC 2006 Supplement |
| Edited by | T. Chandra, K. Tsuzaki, M. Militzer and C. Ravindran |
| Pages | 65-70 |
| DOI | 10.4028/www.scientific.net/AMR.15-17.65 |
| Citation | Serena Danti et al., 2006, Advanced Materials Research, 15-17, 65 |
| Online since | February, 2006 |
| Authors | Serena Danti, Michele Lisanti, Stefano Berrettini, Mario Petrini, Andrea Pietrabissa |
| Keywords | Bone Tissue Engineering, Cancellous Bone Grafts, Demineralized Bone Matrix, Mesenchymal Stem Cell (MSC), Polymeric Scaffolds |
| Abstract | The aim of this report was to investigate the behavior of human mesenchymal stem cells (hMSCs) when cultured on different porous 3D scaffolds, having natural or synthetic origination. Natural scaffolds were obtained by hand made processing of human bone tissue (allograft), because its well known osteoconductive features, using different procedures to eliminate the donor cellular phase. Cancellous bone was frozen, heated or demineralized before being loaded with hMSCs. Among the variety of synthetic materials, biodegradable polymeric spongy matrices were chosen and comparatively tested as scaffolds for hMSCs growth. |
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