Paper Title:

Novel Antibacterial Nanofibers of Chitosan and Polyurethane Prepared by Electrospinning

Periodical Advanced Materials Research (Volumes 150 - 151)
Main Theme Advances in Composites
Edited by Jinglong Bu, Zhengyi Jiang and Sihai Jiao
Pages 1452-1456
DOI 10.4028/
Citation Wei Min Kang et al., 2010, Advanced Materials Research, 150-151, 1452
Online since October 2010
Authors Wei Min Kang, Bo Wen Cheng, Quan Xiang Li, Fang Fang Zuo
Keywords Antibacterial Activity, Chitosan (CS), Electro-Spinning, Polyurethane (PU)
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The chitosan(CS)/polyurethane(PU) blend nanofibers have been prepared for the first time by electrospinning. Formic acid (FA) and Hexafluoroisopropanol (HFIP) were found to be the co-solvent for electrospinning. The CS/PU blend solutions in various ratios were studied for electrospinning into nanofibers. The diameter and morphology of the fibers were shown by scanning electron microscope (SEM). It was found that the average diameter of the chitosan/PU blend fibers became larger, and the morphology of the fibers became finer with the content of PU increasing. To show the molecular interactions, CS/PU fibers were characterized by Fourier transform infrared spectroscopy (FT-IR). Moreover, the antibaterial activity of blend nanofibers against Escherichia coil (E.coil) was measured via optical density method. The blend nanofibers exhibited satisfying antibacterial activity against E.coil, even the chitosan concentration was only 5wt%. Therefore, the spun nanofibers are expected to be used in the native extracellular matrix for tissue engineering.