Paper Title:
Chiral Resolution of Racemic (±)-1,1'Bi (2-Naphthol) by Use of Molecularly Imprinted Polymers
  Abstract

Polymers imprinted with (S)-(-)-1,1’-bi (2-naphthol) and (R)-(+)-1,1’-bi (2-naphthol) have been prepared by non-covalent imprinting. A combinational procedure was used to optimize the functional monomer and crosslinker. A copolymer of 2-vinylpyridine and divinylbenzene resulted in the best chiral recognition. The ratio of template to functional monomer and solvent in the pre-polymerization mixture were also optimized. The imprinted polymers were used as stationary phases in high-performance liquid chromatography (HPLC). The molecularly imprinted polymers (MIPs) were more selective when prepared using a less polar solvent. Effective separations of the enantiomers of racemic (±)-1, 1’-Bi (2-naphthol) were achieved by use of acetonitrile as mobile phase; no cross-selectivity was observed. Interactions between functional monomers and template were investigated by 1H NMR spectroscopy. The results suggest that hydrogen-bonding between the functional monomer and the template and π-π stacking interaction between the cross-linker and the template may contribute to chiral recognition.

  Info
Periodical
Advanced Materials Research (Volumes 150-151)
Edited by
Jinglong Bu, Zhengyi Jiang and Sihai Jiao
Pages
150-159
DOI
10.4028/www.scientific.net/AMR.150-151.150
Citation
H. X. Dong, F. Tong, J. Q. Li, Z. X. Wang, Y. H. Wang, X. D. Shen, "Chiral Resolution of Racemic (±)-1,1'Bi (2-Naphthol) by Use of Molecularly Imprinted Polymers", Advanced Materials Research, Vols. 150-151, pp. 150-159, 2011
Online since
October 2010
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