Co-based WC powder and self-fluxing alloy powder Ni60A were sprayed on hot work die steel H13 substrate via high velocity oxygen fuel (HVOF) spray processing, and microstructure and mechanical properties of two types of coatings were investigated. For WC-12Co coating, some pores were observed, while microcracks were only observed in Ni60A coating, which leads to the lower microhardness and abrasion-resistance at either room temperature or high temperature. At the junction of H13 substrate and WC-12Co coating, metallurgical combination was observed. Under the test condition of load 250g and rotating speed 448r/min, the average friction coefficients obtained at 10 are 0.33 and 0.35 respectively; when the test temperature was 500 , the value of two types of coatings increase to 0.56 and 0.63 respectively. Compared with Ni60A coating, The WC-12Co coating had an excellent abrasion-resistance at high temperature; the weight loss was only one-fifth of the Ni60A coating.