The natural villous bamboo fiber is a kind of debris that product in the process of natural bamboo fiber production. Using villous bamboo fiber to product MDF, bamboo resources can be fully used, and this can perfect the natural bamboo fiber production chain. For determining the optimum technological parameters of villous bamboo fiber MDF, the relationship between the technological parameters and the performances are discussed in this paper. By comparing the GB/T11718-1999 MDF standards, we found the villous bamboo fiber MDF with optimum technological parameters that cost is low, performance is moderate. It’s in line with the requirements of large-scale production.