Finite element method and optimization method are two major ones in engineering analysis. The optimization of a wedged-ring joint structure can be performed by using these two methods unitedly. The response surface design method was employed to determine the combination of geometrical parameters to be designed of the wedged-ring joint structure. The stress of the wedged-ring joint structure which has the different geometrical parameters was numerically simulated and analyzed by using engineering software ANSYS. The optimized geometrical parameters of the wedged-ring structure were obtained by using MATLAB multi-objective optimization method. The results show that the maximum stress and the mass of the optimized wedged-ring structure decrease 13.6% and 12.5%, respectively.