The aim of the present work was to study the feasibility of wet synthesizing hydroxyapatite (HAP) with star-like and high specific surface area. HAP was synthesized by one-step self-assembly process in ionic liquid media under microwave irradiation, and treated at 300, 600, 900 , respectively. X-ray diffraction (XRD) and Fourier transform infrared spectroscopy (FTIR) analysis revealed that HAP was pure crystal phase. Nitrogen adsorption and desorption isotherms (NADI) with a characteristic hysteresis loop further confirmed the existence of uniform micropores or channels of HAP. The BET surface area, pore volume, and pore size distribution were calculated to be 324m2g-1, 0.39cm3g-1, and 3.28 nm, respectively. Scanning electron microscopy (SEM) results indicated that the HAP was of star-shaped morphology. The formation of HAP could be explained by functional ionic liquid as structure-directing template. Well-ordered mesostructure of HAP with star-like might be therefore used as a potential biomaterial for preparation of bone implant materials.