Paper Title:
Preparation of Folate Conjugated O-Carboxymethyl Chitosan Nanoparticles
  Abstract

Anticancer drugs are always restricted as lacking of tumor cell-selective targeting. In this paper, to achieve double effects of targeting and decreasing the drug toxicity, the folate (FA) -O-carboxymethyl chitosan (O-CMC) and the methotrexate (MTX) encapsulated FA-O-CMC/CaCl2 nanoparticles were prepared. The numbers of FA conjugated to O-CMC, particle size, surface morphology, encapsulation efficiency and loading efficiency of the obtained nanoparticles were characterized. The results showed that the FA-O-CMC possessing targeting ability was achieved. MTX had been successfully loaded into the nanoparticles. The prepared nanoparticles were spherical in morphology with an average size of 322 nm

  Info
Periodical
Advanced Materials Research (Volumes 152-153)
Edited by
Zhengyi Jiang, Jingtao Han and Xianghua Liu
Pages
1797-1800
DOI
10.4028/www.scientific.net/AMR.152-153.1797
Citation
J. G. Ji, D. J. Wu, J. F. Zhang, J. J. Li, Y. Xu, "Preparation of Folate Conjugated O-Carboxymethyl Chitosan Nanoparticles", Advanced Materials Research, Vols. 152-153, pp. 1797-1800, 2011
Online since
October 2010
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Price
$32.00
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