Nanometer calcium titanate immobilized on Aluminum oxide (ACTO) was successfully prepared by the citrate acid sol-gel method and characterized using X-ray diffraction (XRD) and scanning electron microscopy (SEM). The adsorption capability of ACTO for Pb2+, Cd2+and Zn2+ from water was studied. Adsorption and elution were investigated under different conditions. The results show that nanometer calcium titanate could be immobilized on the aluminum oxide firmly, becoming a composite adsorbent. The Pb2+, Cd2+and Zn2+ were retained at pH 5-9, their adsorption capacities of ACTO were 124 mg•g-1, 8.58 mg•g-1 and 13.86 mg•g-1, respectively. The adsorption agent can be regenerated by elution with 2 mol•L-1 HNO3. The adsorbent has a promising prospect in removal or enriching and separation of heavy metals in water.