In this paper, results concerning the microstructure of Rene N4 alloy layers produced by laser cladding on oriented CMSX-4 single crystal substrates are presented. The microstructure of the deposits was analyzed in the solidification condition after different temperature/time ageing cycles in order to assess the possibility of improving high temperature strength of laser deposited superalloys. The present work demonstrates that single crystalline deposits of René N4 nickel superalloy can be obtained provided that the deposition direction and the processing parameters are properly selected. The clad layer is perfectly bonded to the substrate and presents no pores or cracks. The deposits grow epitaxially on the substrate, so they inherit its orientation. For laser beam powers and scanning speeds varying between 500 to 800 W and 4 to 12 mm/s, respectively and (001) substrates, the deposited material presents a columnar dendritic structure consisting of arrays of similarly oriented dendrites, separated by subgrain boundaries, forming a single crystal. Heat treatments effective for the dissolution of detrimental phases and for inducing the precipitation of cuboid ’-Ni3Al strengthening phase precipitates in the laser clads were established.