In this paper, puts forward a kind of design method of multi-disciplinary engineering education for product design and development. In educational globalization era, higher education has paid more and more attention to cultivate innovation type of talents, who should receive interdisciplinary education. Mechanical design is an integrative subject. Every student should have a basic ability to finish a product design or plan. As a good mechanical engineer or product designer, should know different kinds of knowledge such as mechanical, materials science, industrial design, economics and so on. Along with the development of higher education popularization, the universities pay more and more attention to the talent cultivation and fusion. Followed by many scholars at home and abroad for interdisciplinary teaching research, its essence is expounded. But although the concept of education that interdisciplinary described the basic form, but to carry out interdisciplinary education in college education environment is not easy even if everyone knows it is very important. In order to solve this problem, the first thing is to break through the traditional education ideas, the second is to set an interdisciplinary teaching organization, the third one is to build a set effective incentive mechanism. So in the paper, puts forward a design method of multi-subjects amalgamation during the education of product design and development.