With the purpose of clothing thermal-wet comfort, this paper chooses clothing materials to be the object of study. The research focuses on how performances of clothing materials and parameters which affect performances of clothing materials influence on clothing comfort. And this paper is proposed that "Fiber - Yarn - Fabrics - Clothing" can be made as the research system for the first time in the field of clothing thermal-wet comfort studying. According to the experiments, it analysis that these three variables— “fibers”, “yarn properties” and “fabric performance”— affect clothing thermal-wet comfort. Based on the contrastive analysis of test result, it can gain the effect of these three variables on clothing comfort. The result is, 1, in these three variables, the effect of yarn fineness on thermal insulation is the highest level of significance, and the second one is fibrousrawmaterials. 2,under the situation which other two ones among these three variables are constant in chosen laboratory samples of this paper, the knitting fabric which is with the cotton fabric, 14.6tex, jacquard weave is the best comfortable.