Low alloy steels such as ASTM A508 and A533 and their equivalent materials have been extensively applied in fabricating pressure vessels due to their relatively excellent mechanical properties and moderately good weldability. The integrity of such materials governs the safety of the power plants. These vessels mainly are subjected to random loading in service and the load cycle interactions can have a significant effect in fatigue crack growth. Studying of fatigue crack growth rate and fatigue life calculation under spectrum loading is important for the reliable life prediction of vessels. Many models have been proposed, but as yet no universal model exists. In this paper, a fatigue life predicted under various load spectra, using three different fatigue crack growth models namely the Austen, modified Forman and NASGRO models. These models are validated with fatigue crack growth test data under various variable amplitude loadings. This application is performed with aids of three-point bend specimens. The results show clearly the load sequences effect and the predicted results agree with some discrepancies between the different models as well as with the test data. Neglecting, the cycle interaction effects in fatigue calculation under variable amplitude loading lead to invalid life prediction.