The number of high-rise reinforced concrete (RC) buildings is steadily increasing since 1980’s. The use of high strength concrete is indispensible for high-rise RC construction to ensure sufficient strength of the structure. The effect of high strength concrete can be significantly improved by the use of high strength and large size reinforcing bars. The yield strength of transverse reinforcement is limited in the current design codes to prevent possible sudden concrete failure due to over reinforcement. This paper presents the effects of the yield strength of transverse reinforcement and compressive strength of concrete on the structural behavior of reinforced concrete cylinders. Two parameters were considered in this investigation: compressive strength of concrete and the yield strength of transverse reinforcement (472MPa, 880MPa, and 1,430 MPa). Analytical and experimental results indicated that the structural behavior of RC cylinders confined with high strength transverse reinforcement is strongly influenced by compressive strength of concrete.