The performance of one full scale four- edge fixed reinforced concrete slab under the condition of combined effects of loading and fire was investigated. The specimens design, the test plan, the test contents and the test methods were firstly introduced. Through the experiments, the distribution of temperature field along the depth of the slab and the temperature changes of the inner steel were obtained, as well as the deformation of out-plane and in-plane and the rotation on the edges. The changing of reaction forces on the bearings of the slab with the temperature was also observed. The results indicated that, under the condition of fire, the out-plan deformation of the slab was much bigger than that of the normal temperature; non-linear temperature filed was existed along the depth of the slab; remarkable redistribution of the reaction forces were occurred on the fixed bearings. The fail pattern of the slab under the condition of combined effects of loading and fire was different from the static loading under normal temperature. The slab was suffered reverse forces because of the heat effects; hence the plastic hinge lines with the shape of elliptic basin were appeared on the top of the slab.