Shrinkage and creep are the inherent properties of concrete bridge. According to Latin Hypercube Sampling method (LHS) and concrete bridge shrinkage and creep uncertainty parameters, this paper promotes stochastic finite element method based on LHS for concrete bridge shrinkage and creep uncertainty analysis in ANSYS random analysis model. Based on this stochastic finite element method, internal force and long-term deformation of a continuous rigid frame bridge with density gradient concrete is analyzed. Result show, internal force and deformation of continuous rigid frame bridge after completing are reasonable and satisfy Code requirement, and are various in previous 3 years at service stage and trend to steadily after 3 years. Research result provides theoretical basis for shrinkage and creep uncertainty further analysis in concrete bridge.