An industrialized multi-layer precast concrete building with middle-joint beams and columns frame system has been developed by China VANKE CO., LTD. The building is the first industrialized multi-layer precast concrete building for experimental purpose in China. A middle-joint beams and columns method has been utilized with beams and columns split in the middle place. The whole frame structure is then integrated into a unity through precast beams, precast columns, and reliable cast-in-place column-column and beam-beam joints. This paper presents the key points and difficulties during the building design process, introduces the structural design of column-column and beam-beam joints, and analyses the advantages and weaknesses of middle-joint beams and columns frame system.