At present, durability of concrete structures has become one of the problems widely concerned by the academic and engineer circles in civil engineering. Shanghai Yangtze River tunnel project is the engineering background of the paper. The sensitivity analysis has been studied on carbonization life's influencing factors of Shanghai Yangtze River Tunnel segment structure with the method of grey -correlation theory and uniform design. The results show that concrete cover depth has the most important effect. The other less important influencing factors in turn are as follows: concrete compressive strength, fly ash substitution amount, temperature, relative humidity and CO2 concentration. The research achievement has been using in the design and construction of Yangtze River Tunnel, and good results have been achieved.