Differential settlement of the new foundation was produced after the building monolithic moving was finished. The internal forces of the top building were changed due to the existence of the differential settlement and the original differential settlement, which affected structural safety. A three-dimensional finite element model was established based on the ANSYS program to attain the foundation settlement law of a fifteen-story moving building. Through calculation and comparation of the settlement values and differential settlement between slab foundation and pile foundation, the pile foundation was finally selected as the construction scheme. Simultaneously, numerical analysis of foundation differential settlement during the moving process was performed. The monitoring results were showen to be in reasonable agreement with the numerical analysis results.