Pre-stressed steel structures with large space are widely used in stadium, exhibition hall, theater and other buildings today. In order to study the fire-resistance behavior of suspended steel lattice shell of a stadium, the method of performance-based fire resistance design is used. First of all, the stadium physical model is established and the software FDS is used to determine the heating curves of the measuring points of the large space structure for two fire scenes. Compared with international standards heating curve, the heating curves of the large space structure obtained here has characteristic of local high-temperature. The finite element software MSC.MARC is further used to simulate the fire behavior of the pre-stressed steel structure with large space, in which the fire scene with 10MW design power of fire source and 30 minutes duration of fire are considered and two loading ways that overall non-uniform temperature field loading and the local high temperature components loading are accepted. The results show that the pre-stressed steel structure with large space has good fire resistance behavior, and the overall failure will not take place for the fire scene suggested here during 30 minutes duration of fire.