The feature of the concrete grid-frame structure with specially shaped columns is the frame beams and specially shaped columns in the walls were divided by rib beams and rib columns, then the rib beams, the rib columns, the frame beams and the specially shaped columns together constitute the grid-frame structures with specially shaped columns. The rib beams and the rib columns can share parts of the vertical and horizontal loads which the structure should bear and work together with the frame beams and the specially shaped columns, so make the lateral stiffness of the structure is increased and the ultimate strength, ductility and seismic performance of the structure are improved. Moreover, Phosphorus gypsum will be poured to enclose concrete beams and columns and become the filler wall among them. At the same time, phosphorus gypsum wallboards are used as the middle filler walls to separated rooms flexibly. By doing so, the building is more energy saving. In addition, the phosphorus gypsum which is a type of industrial waste can be consumed and become useful material in construction.