pavement performance of SEBS modified asphalt mixture are analyzed. Dynamic shear rhometer(DSR) experiments were performed to evaluate the rheology properties of SEBS modified asphalt binder and performance of SEBS modified asphalt mixture was evaluated based on laboratory experiments, experiments included: wheel tracking, moisture susceptibility, low-temperature beam bending and fatigue. The results shows that the rheology properties of SEBS modified asphalt binder are more ideal than SBS modified asphalt binder on anti-fatigue effect. Tensile stress ratio(TSR) of SEBS modified asphalt mixture increases 5.0%, tensile strength increases 6.1% and tensile strain increases 19.8%, though the dynamic stability(DS) decreases 3.1%, the fatigue life-span increases significantly compared with SBS modified asphalt mixture. It means that pavement performance of SEBS modified asphalt mixture is better than SBS modified asphalt mixture, and it is more applicable to be utilized in highway engineerings and some special engineerings such as bridge deck pavement that need anti-fatigue performance.