Large-scale public buildings have high energy density, which take big part of the gross energy consumption in buildings in China. It is still in attempting stage about the strategy of energy conservation in air conditioning systems. The objective of this study is to investigate that how to appropriately divide central air conditioning system zoning by using simulation software to calculate the basis dynamic temperature and load in typical large-scale public buildings. Effects of weather conditions, building envelope conditions and building structure on large-scale public building energy consumption were analyzed in this simulation. The results show that the building load is the fundamental factor involved in air conditioning system zoning. Surplus heat recovery in inner zone is also recommended to maintain inner zone comfort and energy conservation. This work provides the theoretical and technological basis for study on central air conditioning system zoning and thermal comfort for large-scale public building.