Based on a new type of sprayed liquid desiccant total heat recovery device, a liquid desiccant system combined refrigeration system with the independent humidity control (IHC) strategy is presented, in which the entire latent load and part of the sensible load are removed by liquid desiccant fresh unit combining heat pump (LFUH). The air-conditioning cooling load of a commercial building is simulated by DEST software. And the energy consumption is calculated respectively for conventional air conditioning system and IHC system. Compared with ordinary systems, IHC system can achieve savings of about 20% of the power consumption per annum. In addition, the average coefficient of chiller performance (COP) can increase about 13.5%. The result sows that IHC system has better application prospects.