With the continuous development of printing technology and printing equipments, the quality of newsprint should be improved to meet with all the real demands. Acrylamide copolymer is used in paper-making as process aid and function aid which can effectively improve paper printing adaptability. Preparation and application of polyacrylamide via aqueous copolymerization was studied as dry strength agent in this paper. The polyacrylamide with middle molecular weight and low viscosity was obtained by reacting acrylamide, cationic monomer [2-(acryloyloxy)ethy] -trimethylammonium chloride and N,N-dimethylaminoethyl methacrylate, anionic monomer itaconic acid, active nonionic monomer N-metholacrylamide and crosslinking monomer 1,3,5-triacryloylhexahydro-s-rine, the copolymer was characterized by FT-IR, charge density and molecular weight distribution. On the basis of internal present situation of pulp, the papermaking system with deinking pulp from office waste paper and white water of 1000-1200us/cm conductivity from paper mill were selected for application research. The results show that when the dosage of acrylamide copolymer is 0.8% to the dry weight of pulp and handsheet basis weight is 60g/m2, acrylamide copolymer can show the superior performance to newsprint and receivable cost for paper mill, fluffing speed, tearing strength and internal bonds are respectively improved by 14%, 20% and 30%.