In the paper, the spot-color was divided into ten color areas based on the theory of Munsell color system, then, the model samples in IGT was produced according to each color area. After measuring and analyzing the data of the proofs, Gravure spot-color matching based on masking equation by the means of ten color areas was established. Finally, the paper validated the precision of Gravure spot-color matching model by the method of color difference. The functional module of Gravure spot-color matching in the commercial spot-color matching system was developed using C++ programming language and MySQL Database. The running result of spot-color matching software indicated that the Gravure spot-color matching system based on the proposed method is easy to come true by computer programming, and the color difference between matching color and target color is suitable range (△E≤6 ).