Paper Title:
Study on Silk Fibroin Gelation: Effect of Polyalcohol
  Abstract

The Bombyx mori silk fibroin gel with three dimensional structures is an important form to be developed for tissue engineering materials. In this paper, silk fibroin gels were prepared with adding polyalcohol into silk fibroin solution. The gel structure was analyzed by X-ray diffraction, Fourier transform infrared spectroscopy and scanning electron microscopy. The results demonstrated that when adding more than 100% of polyalcohol, both of glycerol and polyethylene glycol 400 (PEG400) can accelerate the gelation process markedly. With the increase of the percentage of PEG400 and glycerol, it promoted silk fibroin molecules to cluster rapidly and inhibit silk fibroin molecules transforming from the random coil or α-helix to β-sheet in a ratio of 900% especially. Silk fibroin gels containing 100% of polyalcohol had more uniform morphology and the pores distributed uniformly.

  Info
Periodical
Advanced Materials Research (Volumes 175-176)
Main Theme
Edited by
Lun Bai and Guo-Qiang Chen
Pages
137-142
DOI
10.4028/www.scientific.net/AMR.175-176.137
Citation
Q. Zhang, Y. D. Cheng, Y. Liu, S. Q. Yan, M. Z. Li, "Study on Silk Fibroin Gelation: Effect of Polyalcohol", Advanced Materials Research, Vols. 175-176, pp. 137-142, 2011
Online since
January 2011
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Price
$32.00
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