Paper Title:
Preparation and Characterization of Electrospun Silk Fibroin-Based Tubular Scaffolds
  Abstract

Artificial nerve conduits (NC) can be used as an alternative to autologous nerve grafts to enhance the repair of small nerve gaps. Many natural and synthetic biomaterials have been processed to be tubular scaffolds. However, current NC lack adequate molecular and structural functionalities. Thus, we prepared silk fibroin (SF)-based nanofibrous tubular scaffolds (inner diameter=1.5 mm) for nerve repair. The Bombyx mori silk fibroin was firstly dissolved in hexafluoroisopropanol (HFIP), and then was electrospun to be nanofibrous silk fibroin tube which topographically functionalized with aligned and non-aligned SF nanofibers. Effects of electrospinning parameters (including collection distance, rotational speed and translational speed) on the micro-morphology of SF tube were investigated. The nanofibers orientation in SF tube affects the mechanical property of SF tube. The results suggest that this tubular scaffold shows promising application in nerve tissue engineering.

  Info
Periodical
Advanced Materials Research (Volumes 175-176)
Main Theme
Edited by
Lun Bai and Guo-Qiang Chen
Pages
197-201
DOI
10.4028/www.scientific.net/AMR.175-176.197
Citation
J. W. Huang, F. Zhang, B. Q. Zuo, Z. H. Fan, H. X. Zhang, "Preparation and Characterization of Electrospun Silk Fibroin-Based Tubular Scaffolds", Advanced Materials Research, Vols. 175-176, pp. 197-201, 2011
Online since
January 2011
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