In order to take the advantage of the specific property of sericin to improve wear property of cotton fabric, cotton fabric was finished with sericin. Sericin was fixed onto the surface of cotton fabric in the presence of poly-carboxylic acids (CA and BTCA) at high temperature using a pad-dry-cure process. The effects of catalyst concentration, pH value, curing temperature and curing time on the finish were investigated. The optimized finishing conditions for cotton fabric were obtained. The weight gain of treated fabric with BTCA as crosslinking agent was higher than CA. The whiteness, breaking strength, moisture regain, permeability to gas and crease recovery properties of treated fabrics were measured. The results showed that wrinkle recovery angle evidently increased, and the wrinkle recover angle of BTCA combined secrin treated fabric was higher than CA. The breaking strength, moisture regain and whiteness of the treated fabric slightly decreased, the permeability to gas of cotton fabrics were not changed.